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For instance, emerging evidence suggests that genotype and endogenous opioid functioning play a causal role in these disparities, and considerable literature implicates sex hormones as factors influencing pain sensitivity.If you are experiencing any online connection issues the first thing you should do is clear the cache on your browser and attempt to reconnect. If you like this website, then please recommend it to all your friends and family that you think are interested. The system will automatically determine whether you are on such a device, and a button will appear which you can click to go into the room.Please do not forget to check out one of the best free chat site on the net. So, if this sort of chat does not suit you or you are underage, please go to: #1 Chat Avenue (Not a sex chat) * Please do take notice that from time to time we may experience technical difficulties or maintenance.However, the specific modulatory effect of sex hormones on pain among men and women requires further exploration.Psychosocial processes such as pain coping and early-life exposure to stress may also explain sex differences in pain, in addition to stereotypical gender roles that may contribute to differences in pain expression.Therefore, this review will provide a brief overview of the extant literature examining sex-related differences in clinical and experimental pain, and highlights several biopsychosocial mechanisms implicated in these male–female differences.